Visualized Analyses of Investigations Upon Mesenchymal Stem/stromal Cell-based Cytotherapy and Underlying Mechanisms...

Area of Science:

• * Focuses on the intersection of virology, immunology, and regenerative medicine.
• * Explores therapeutic strategies for severe respiratory infections and critical care.

Background:

• * The COVID-19 pandemic, caused by SARS-CoV-2, poses a significant global health threat.
• * Severe COVID-19, particularly ARDS, is associated with high mortality and morbidity.
• * Mesenchymal stem/stromal cell (MSC) therapy is emerging as a potential treatment for ARDS.

Purpose of the Study:

• * To systematically analyze and visualize the landscape of MSC-based cytotherapy for ARDS.
• * To identify key research trends, core contributors, and emerging themes in MSC-ARDS research.
• * To summarize the molecular mechanisms, safety, and efficacy of MSC therapy for ARDS.

Main Methods:

• * Bibliometric analysis utilizing visualization software.
• * Analysis of publication trends, core authors, institutions, and keywords related to MSCs and ARDS.
• * Review of clinical trial data on the safety and efficacy of MSC-based therapy for ARDS.

Main Results:

• * Provides a comprehensive overview of the evolution and current state of MSC-ARDS research.
• * Identifies leading authors, institutions, and research hotspots in the field.
• * Summarizes existing knowledge on molecular mechanisms and clinical outcomes of MSC therapy for ARDS.

Conclusions:

• * MSC-based therapy represents a promising avenue for managing ARDS, including that associated with COVID-19.
• * Bibliometric analysis offers valuable insights into the research dynamics and knowledge structure of MSC-ARDS therapy.
• * Further research and clinical trials are warranted to optimize MSC therapy for ARDS.