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Signaling pathways associated with structural changes in varicose veins: a case-control study.
Mohamad Hadi Saeed Modaghegh1, Shirin Saberianpour1, Sakineh Amoueian2
1Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Phlebology
|July 13, 2021
Summary
Varicose veins show increased collagen and elastin, altered nitric oxide levels, and changes in gene expression related to matrix remodeling and aging. These factors contribute to the structural and functional changes seen in this condition.
Area of Science:
- Vascular Biology
- Molecular Medicine
- Biochemistry
Background:
- Varicose veins involve increased venous pressure and structural remodeling in lower extremities.
- Understanding the molecular mechanisms behind these changes is crucial for effective treatment.
Purpose of the Study:
- To assess signaling pathways linked to structural alterations in varicose veins.
- To investigate oxidative stress markers and gene expression profiles in varicose veins.
Main Methods:
- Histopathological examination using H&E, trichrome, and elastin staining.
- Measurement of oxidative stress markers (MDA, total thiol, SOD, NO) via ELISA.
- Real-time PCR to determine gene expression of MMP2, MMP9, FOXO3a, APOE, and p53.
Main Results:
- Increased collagen and elastin accumulation in varicose vein walls.
- Elevated nitric oxide and thiol levels in varicose veins.
- Upregulated MMP2 and p53 gene expression; downregulated FOXO3a and APOE expression.
Conclusions:
- Varicose veins exhibit distinct changes in oxidative stress, morphology, and aging pathways compared to healthy veins.
- These alterations in oxidative stress, structure, and aging likely play a role in varicose vein development.
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