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One-year change in plasma volume and mortality in the Japanese general population: An observational cohort study

Yoichiro Otaki1, Tetsu Watanabe1, Tsuneo Konta1

  • 1Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.

Plos One
|July 13, 2021
PubMed

Insights

A 1-year change in plasma volume is a newly identified risk factor for mortality in the general population. This finding could aid in predicting risks for cardiovascular and cancer deaths.

Area of Science:

  • Cardiovascular Medicine
  • Public Health
  • Biostatistics

Background:

  • Plasma volume changes are recognized indicators of expansion and contraction.
  • These changes are increasingly important in managing heart failure.
  • Their role as a mortality risk factor in the general population was previously unknown.

Purpose of the Study:

  • To investigate if a 1-year change in plasma volume predicts mortality risk.
  • To determine if this change is a risk factor for all-cause, cardiovascular, and non-cardiovascular deaths.

Main Methods:

  • Utilized a nationwide Japanese health database of 134,291 individuals aged 40-75.
  • Calculated 1-year plasma volume change using the Strauss-Davis-Rosenbaum formula.
  • Employed Kaplan-Meier analysis and multivariate Cox proportional hazard regression.

Main Results:

  • The highest quintile of 1-year plasma volume change showed the greatest mortality risk.
  • A 1-year change in plasma volume independently predicted all-cause, cardiovascular, non-cardiovascular, and cancer deaths.
  • Incorporating plasma volume change improved cardiovascular risk prediction models.

Conclusions:

  • A 1-year change in plasma volume is a novel, independent risk factor for mortality.
  • This includes risks for all-cause, cardiovascular, and non-cardiovascular (primarily cancer) mortality.
  • Plasma volume change offers additional prognostic value beyond traditional risk factors.
Abstract

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