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Updated: Oct 29, 2025

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
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Laser therapy for dentinal hypersensitivity.

Mina Mahdian1, Soodabeh Behboodi2, Yumi Ogata3

  • 1Department of Prosthodontics and Digital Technology, Stony Brook University School of Dental Medicine, Stony Brook, NY, USA.

The Cochrane Database of Systematic Reviews
|July 13, 2021
PubMed
Summary
This summary is machine-generated.

Laser therapy may reduce pain from dentinal hypersensitivity compared to placebo or no treatment. While generally safe, more high-quality research is needed to confirm its effectiveness and cost-effectiveness.

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Area of Science:

  • Dentistry
  • Biomedical Engineering
  • Pain Management

Background:

  • Dentinal hypersensitivity presents as sharp pain from exposed dentin due to external stimuli.
  • Laser therapy is an emerging intervention for managing dentinal hypersensitivity.

Purpose of the Study:

  • To evaluate the efficacy of in-office laser treatments versus placebo or no treatment for dentinal hypersensitivity pain relief.

Main Methods:

  • A systematic review and meta-analysis of randomized controlled trials (RCTs) comparing lasers to placebo/no treatment.
  • Searched multiple databases up to October 2020, including Cochrane Oral Health's Trials Register, CENTRAL, MEDLINE, Embase, CINAHL, and LILACS.
  • Included 23 RCTs with 936 participants; meta-analyses were performed on 17 studies.

Main Results:

  • Laser therapy showed a reduction in pain intensity for air blast stimuli at short, medium, and long terms (low to very low-certainty evidence).
  • Pain reduction was also observed for tactile stimuli at short and medium terms (low to very low-certainty evidence).
  • No significant adverse events were reported, but long-term tactile stimulus data was insufficient.

Conclusions:

  • Limited evidence suggests laser therapy may improve pain intensity for dentinal hypersensitivity.
  • Laser therapy appears safe, but further well-designed RCTs are needed to confirm efficacy and cost-effectiveness.