Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative analysis of the cellular landscape in mammalian striatum.

Nature communications·2026
Same author

Frequency of mixed neuropathologies in individuals with down syndrome with and without Alzheimer's dementia.

Acta neuropathologica·2026
Same author

Homologous specialization of arcuate fasciculus ventrolateral frontal connectivity in marmosets and humans.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Morphological and anatomical variations in subcortical anatomy between humans and chimpanzees associated with heritability patterns related to human behavioral traits.

Communications biology·2026
Same author

Psychometric criteria for superior cognitive performance in very old adults.

Journal of Alzheimer's disease : JAD·2026
Same author

Cerebrospinal fluid and frontal cortex TMPRSS2 and ACE2 protein levels differ in Down syndrome and Alzheimer's disease.

Acta neuropathologica communications·2026
Same journal

Validating a Mixed Qualitative Behavioral Assessment for Adult Western Lowland Gorillas (Gorilla gorilla gorilla) II: Significant Event Monitoring.

American journal of primatology·2026
Same journal

Behavioral Flexibility and the Conservation Value of Howler Monkey Populations in Small Habitat Patches.

American journal of primatology·2026
Same journal

Investigating Multimodal (Visual, Acoustic, and Thermal) Ovulatory Signaling in a Non-Human Primate Species (Cercocebus torquatus).

American journal of primatology·2026
Same journal

Lemur Distribution in Relation to Treefall Canopy Gaps in Masoala National Park, Northeast Madagascar.

American journal of primatology·2026
Same journal

Genetic Characterization of MAOA and OXTR in Western Lowland Gorillas (Gorilla gorilla gorilla).

American journal of primatology·2026
Same journal

Correction to "Insights Into Variations in the Gut Virome of Tibetan Macaques (Macaca Thibetana) Across Wild, Captive, and Semi-Provisioned Environments".

American journal of primatology·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

10.3K

Comparative neuropathology in aging primates: A perspective.

Carmen Freire-Cobo1, Melissa K Edler2,3,4, Merina Varghese1

  • 1Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

American Journal of Primatology
|July 13, 2021
PubMed
Summary
This summary is machine-generated.

Non-human primates (NHP) show varied brain aging, offering insights into brain senescence without typical human neurodegenerative diseases. Studying NHP neuropathology reveals cellular changes impacting cognition.

Keywords:
brain senescenceglianeuron morphologynon-human primatesproteinopathy

More Related Videos

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.6K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K

Related Experiment Videos

Last Updated: Jun 9, 2026

Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

10.3K
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.6K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K

Area of Science:

  • Neuroscience
  • Comparative Pathology
  • Primatology

Background:

  • Human aging involves significant neuropathology and cognitive decline.
  • Non-human primates (NHP) display variable age-related brain changes, making them valuable models.
  • Captive NHP allow studying brain senescence independent of common human neurodegenerative diseases.

Purpose of the Study:

  • To provide a comparative overview of neuropathological changes across the primate order during aging.
  • To review cellular and ultrastructural data on neuronal and synaptic alterations in aging primates.
  • To discuss the functional consequences of age-related neuropathology on cognition.

Main Methods:

  • Comparative analysis of existing neuropathological observations in various primate species.
  • Review of cellular and ultrastructural studies on neuronal, synaptic, axonal, and myelin pathology.
  • Synthesis of data on age-related changes like cell loss, amyloid deposition, and tau accumulation.

Main Results:

  • Age-related changes vary across primate species and individuals.
  • Documented changes include cell loss, amyloid deposition, amyloid angiopathy, and tau accumulation.
  • Neuronal alterations involve dendritic attrition, synaptic pathology, and axonal/myelin changes.

Conclusions:

  • NHP serve as crucial models for understanding brain senescence and its functional impact.
  • Comparative neuropathology in primates highlights diverse aging trajectories.
  • These findings inform research on cognitive aging and potential interventions.