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Socioeconomic Disparities in Non-Small Cell Lung Cancer With Brain Metastases at Presentation: A Population-Based
Ignacio Jusue-Torres1, Alicia Hulbert2, Jehad Zakaria1
1Department of Neurological Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois, USA.
World Neurosurgery
|July 13, 2021
Summary
Patients with non-small cell lung cancer (NSCLC) and brain metastases who live in higher income areas have better survival rates. This highlights the need for equitable healthcare access for all patients, regardless of economic status.
Area of Science:
- Oncology
- Public Health
- Health Economics
Background:
- Non-small cell lung cancer (NSCLC) with brain metastasis presents a significant survival challenge.
- Socioeconomic factors, particularly household income, may influence patient outcomes.
Purpose of the Study:
- To investigate the association between household income disparities and survival in patients with NSCLC and brain metastases.
- To analyze the impact of income on a population-based level.
Main Methods:
- A population-based cohort study utilizing the SEER database (2010-2016).
- Inclusion of 15,808 adult patients diagnosed with NSCLC and brain metastases.
- Multivariate Cox proportional hazard analysis to assess survival based on household income quartiles.
Main Results:
- Patients in higher household income quartiles demonstrated significantly increased survival rates at 1, 2, and 5 years.
- Higher income was independently associated with increased survival (HR 0.87, 95% CI 0.82-0.92, P < 0.0001).
- Survival rates ranged from 21% (1-year) in the lowest quartile to 31% (1-year) in the highest quartile.
Conclusions:
- Higher median household income is linked to improved survival and reduced mortality risk for NSCLC patients with brain metastases.
- These findings emphasize the critical need for equitable access to healthcare, irrespective of socioeconomic background.
- Addressing income-related disparities is crucial for enhancing cancer patient outcomes.
