Related Experiment Video

Updated: Oct 29, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

393

Growth Hormone and Insulin-Like Growth Factor Dysregulation in Pediatric Chronic Kidney Disease

Denver D Brown1,2, Andrew Dauber2,3

  • 1Division of Nephrology, Children's National Hospital, Washington, District of Columbia, USA.

Hormone Research in Paediatrics
|July 13, 2021
PubMed

Insights

Children with chronic kidney disease (CKD) often experience poor growth due to issues with the growth hormone (GH) and insulin-like growth factor (IGF) axis. Therapies targeting this axis offer potential solutions for short stature in pediatric CKD.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Growth Disorders

Background:

  • Poor growth is a significant complication in pediatric chronic kidney disease (CKD), impacting long-term outcomes.
  • The causes of impaired growth in children with CKD are complex and multifactorial.

Purpose of the Study:

  • To review the role of the growth hormone (GH) and insulin-like growth factor (IGF) axis in growth impairment in pediatric CKD.
  • To explore the impact of metabolic acidosis on the GH/IGF axis and growth in this population.
  • To present current and potential therapeutic strategies for short stature in pediatric CKD.

Main Methods:

  • Literature review of studies investigating growth, GH/IGF axis, and metabolic acidosis in pediatric CKD.
  • Analysis of data on GH resistance and IGF bioactivity in relation to growth failure.
  • Examination of the effects of metabolic acidosis on hormonal regulation and growth.

Main Results:

  • Dysregulation of the GH/IGF axis, including GH resistance and altered IGF levels/bioactivity, is implicated in growth failure.
  • Metabolic acidosis may negatively affect the GH/IGF axis and contribute to impaired growth in pediatric CKD.
  • Various therapeutic approaches targeting the GH/IGF axis are being explored for short stature.

Conclusions:

  • The GH/IGF axis plays a critical role in growth regulation and is frequently disrupted in pediatric CKD.
  • Addressing metabolic acidosis and targeting the GH/IGF axis are key strategies for managing short stature in children with CKD.
  • Further research into GH/IGF axis therapies holds promise for improving growth outcomes.

Keywords:
Chronic kidney diseaseGrowthGrowth hormonePediatrics

More Related Videos

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

10.0K
Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

2.0K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
286
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
156
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
199
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
37
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
92
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
341