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Updated: Oct 29, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
Cavity macrophages stop anti-tumor T cells
Paulo C Rodriguez1, Brian Ruffell2
1Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
None:
Precisely how macrophages regulate response to immunotherapy remains unclear. In this issue of Cancer Cell, Chow et al. demonstrate a tumor-promoting role of TIM-4+ cavity macrophages which affects the response of metastatic malignancies to immunotherapy. Specifically, TIM-4+ macrophages engage with phosphatidylserine-expressing cytotoxic T lymphocytes, inhibiting their activity even during PD-1 blockade.
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