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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Non-coding RNAs in endodontic disease.

Johnah Galicia1, Asma A Khan2

  • 1Department of Restorative Dentistry (Endodontics), Eastman Dental Institute, University College London, United Kingdom; Department of Endodontics, Arthur A. Dugoni School of Dentistry, San Francisco, CA, United States.

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Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) are crucial for dental pulp immunity and regeneration. Understanding ncRNAs can lead to new treatments for endodontic diseases and promote dentin-pulp complex repair.

Keywords:
DentalEpigeneticMicroRNANon-coding RNASiRNAs

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Area of Science:

  • Endodontics
  • Molecular Biology
  • Immunology

Background:

  • Dental pulp and apical tissues possess immunocompetence and regeneration potential.
  • Research on non-coding RNAs (ncRNAs) in these tissues is emerging.
  • ncRNAs play a role in pulpal and periapical immune responses and dentin-pulp complex regeneration.

Purpose of the Study:

  • To review recent advancements in understanding the role of ncRNAs in endodontic disease.
  • To highlight the function of ncRNAs in the immune response to endodontic infection.
  • To explore the involvement of ncRNAs in the repair and regenerative response to dental pulp injury.

Main Methods:

  • Literature review of current research on non-coding RNAs in endodontics.
  • Analysis of studies investigating ncRNA function in pulpal and periapical tissues.
  • Synthesis of findings related to ncRNAs in immune response and tissue regeneration.

Main Results:

  • ncRNAs are increasingly recognized for their regulatory roles in endodontic tissues.
  • Specific ncRNAs are implicated in modulating immune responses to endodontic infections.
  • ncRNAs show potential in promoting the regeneration of the dentin-pulp complex.

Conclusions:

  • Further investigation into ncRNAs is vital for advancing endodontic treatment strategies.
  • Targeting ncRNAs may offer novel therapeutic approaches for preventing and treating endodontic diseases.
  • Understanding ncRNA mechanisms is key to harnessing the regenerative potential of dental pulp.