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Correlation between Stroke Risk and Systolic Blood Pressure in Patients over 50 Years with Uncontrolled Hypertension:

Rishi Sethi1, J S Hiremath2, V Ganesh3

  • 1Department of Cardiology, KG's Medical University, Lucknow, India.

Cardiovascular Therapeutics
|July 14, 2021
PubMed

Insights

Elevated systolic blood pressure (SBP) in older adults with hypertension significantly increases stroke risk. Lowering SBP is crucial for stroke prevention in India, as diastolic blood pressure showed no significant correlation.

Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Hypertension is a major risk factor for stroke, particularly in older populations.
  • Uncontrolled blood pressure (BP) in patients aged 50 and above poses a significant health challenge.
  • Assessing BP levels and stroke risk is vital for effective hypertension management.

Purpose of the Study:

  • To determine mean systolic and diastolic blood pressure (SBP and DBP) in patients aged 50+ with uncontrolled hypertension (HTN).
  • To evaluate the correlation between BP levels and stroke risk.
  • To identify prescribed therapeutic drug classes for hypertension in this demographic.

Main Methods:

  • A cross-sectional, observational study was conducted across 176 outpatient centers in India.
  • Included patients aged ≥50 years with elevated SBP (≥140 mmHg).
  • Stroke risk was calculated using Stroke Riskometer™ and analyzed against BP and other risk factors using Pearson correlation and logistic regression.

Main Results:

  • 3791 patients (60% male, mean age 62.1 years) had mean SBP of 157.3 mmHg and DBP of 89.8 mmHg.
  • 33.9% had moderate to severe 5-year stroke risk, and 70% had moderate to severe 10-year stroke risk.
  • Each 1 mmHg increase in SBP correlated with a ~4% increase in 5- and 10-year stroke risk (p < 0.0001); DBP showed no significant correlation. Diabetes and smoking significantly increased stroke risk.

Conclusions:

  • A strong association exists between elevated systolic blood pressure and increased stroke risk.
  • Real-world data highlight the need for improved primary stroke prevention strategies in India.
  • Reducing the prevalence of recurrent stroke requires focused public health interventions.
Abstract

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