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CLIPPERS associated with hypersensitivity pneumonitis: a case report
Maria Andrea Parra Corral1, Jose Gavito-Higuera1, Thomas O'Neill1
1Texas Tech University Health Sciences Center El Paso. 4801 Alberta Ave, El Paso, TX 79905.
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare brain condition. Prompt steroid treatment improved patient symptoms and reduced brainstem lesions, suggesting CLIPPERS may be treatable.
Area of Science:
- Neurology
- Immunology
- Radiology
Background:
- Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare and poorly understood neurological condition.
- CLIPPERS is characterized by inflammatory lesions in the brainstem.
Observation:
- A 51-year-old male presented with neurological deficits and recent hypersensitivity pneumonitis.
- Brain imaging revealed multiple punctate enhancing lesions in the brainstem.
Findings:
- The patient's neurological symptoms improved following corticosteroid initiation.
- Follow-up imaging at 6 months showed a decrease in lesion size.
Implications:
- This case highlights the importance of recognizing CLIPPERS and its potential for misdiagnosis.
- Proposed diagnostic criteria may facilitate prompt treatment and prevent neurological sequelae.
- Early steroid intervention appears effective in managing CLIPPERS, improving patient outcomes.
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