Vessel Density and Structural Measurements in Primary Angle-Closure Suspect Glaucoma Using Optical Coherence...

Area of Science:

• Ophthalmology
• Medical Imaging
• Retinal Imaging

Background:

• Primary angle-closure suspects (PACS) are at risk of developing angle-closure glaucoma.
• Early detection and monitoring of structural changes in PACS are crucial for intervention.

Purpose of the Study:

• To compare macular retinal vessel density (VD) and peripapillary retinal nerve fiber layer (RNFL) between PACS and normal subjects using Angio-OCT.
• To identify factors associated with RNFL thickness in PACS.

Main Methods:

• Prospective study comparing PACS patients with normal subjects.
• Assessment of RNFL thickness, retinal VD, and ocular perfusion pressure (OPP) using Optical Coherence Tomography Angiography (OCTA).

Main Results:

• No significant differences in age, sex, intraocular pressure (IOP), or retinal VD between groups.
• PACS group demonstrated significantly thicker RNFL compared to the control group.
• OPP was independently associated with RNFL thickness in the PACS group.

Conclusions:

• OCTA reveals a significant thickening of the RNFL in PACS.
• OPP is the sole independent predictor of RNFL thickness in PACS.