Related Experiment Video
Updated: Oct 29, 2025
03:49
Application of Microwave Ablation in Laparoscopic Partial Splenectomy
Published on: November 15, 2024
314
Isolated splenic high-grade serous carcinoma: A case report
Ralph Rogers1,2, Sarah Ehmann1, William P Tew3,4
1Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gynecologic Oncology Reports
|July 14, 2021
Summary
A rare high-grade serous carcinoma was found exclusively in the spleen. Genetic analysis revealed mutations in PALB2, ARID1, and TP53, offering insights into this unusual presentation.
Area of Science:
- Gynecologic Oncology
- Surgical Pathology
- Cancer Genomics
Background:
- High-grade serous carcinoma (HGSC) typically originates in the ovaries or fallopian tubes.
- Metastatic spread commonly involves the omentum, uterus, and peritoneum.
- Primary splenic tumors are exceedingly rare, especially those of Mullerian origin.
Observation:
- A unique case of HGSC was diagnosed with the primary tumor site isolated to the spleen.
- No evidence of malignancy was found in the ovaries, fallopian tubes, omentum, or uterus.
- Pathological examination confirmed metastatic Mullerian carcinoma.
Findings:
- Multigene tumor panel sequencing (MSK-IMPACT) identified key somatic mutations.
- Mutations were detected in PALB2 and ARID1 genes.
- A TP53 hotspot mutation was also identified.
Implications:
- This case expands the known spectrum of HGSC presentation.
- Understanding the genetic drivers (PALB2, ARID1, TP53) may inform future therapeutic strategies for rare splenic HGSC.
- Highlights the importance of comprehensive molecular profiling in diagnosing unusual cancer presentations.
Keywords:
ARID1 somatic mutationHigh-grade serous carcinomaPALB2 mutationPluripotent spleen cellSplenic Mullerian carcinomaTP53 hotspot mutation
