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A preliminary study on the relationship between sleep, depression and cardiovascular dysfunction in a 4 sample
Adrienne-Denise V Bilbao1, Jennifer Goldschmied1, Angela Jang1
1Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
International Journal of Cardiology. Heart & Vasculature
|July 14, 2021
Summary
Sleep disordered breathing (SDB) is linked to cardiovascular dysfunction in Major Depressive Disorder (MDD) via nitric oxide (NO) dysregulation. Screening for SDB in MDD patients may help predict cardiovascular disease (CVD) risk.
Area of Science:
- Cardiology
- Sleep Medicine
- Psychiatry
Background:
- Major Depressive Disorder (MDD) is associated with worse cardiovascular outcomes, but mechanisms are unclear.
- Sleep Disordered Breathing (SDB) may link MDD and cardiovascular disease (CVD) through inflammation and nitric oxide (NO) dysregulation.
Purpose of the Study:
- To investigate the relationship between cardiovascular dysfunction, sleep difficulties, and MDD.
- To explore the role of SDB and NO bioavailability in the comorbidity of MDD and CVD.
Main Methods:
- Overnight polysomnography and an inflammation panel were used.
- Participants included controls, SDB only, MDD only, and combined SDB and MDD groups.
Main Results:
- A positive correlation between sleep dysfunction and Symmetric Dimethyl Arginine (SDMA), an NO synthesis inhibitor, was found in the MDD-only group.
- SDMA-mediated NO dysregulation is implicated in CVD pathogenesis in MDD patients.
- Hypopneas significantly contributed to the SDB-CVD link in MDD patients.
Conclusions:
- Widespread SDB screening in MDD populations is recommended for early CVD risk detection.
- SDMA presents a potential therapeutic target for CVD in individuals with MDD.
Keywords:
Cardiovascular diseaseHypopneaInterleukin-6Major depressive disorderSleep-disordered breathingSymmetric dimethylarginineMore Related Videos
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