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Serum intact fibroblast growth factor 23 in healthy paediatric population
Malgorzata Stanczyk1,2, Slawomir Chrul3, Krystyna Wyka4
1Department of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Rzgowska 281/289, Lodz 93-338, Poland.
Insights
Fibroblast growth factor 23 (FGF23) levels in healthy children are not dependent on age or sex. This study provides reference data for FGF23 in the pediatric population.
Area of Science:
- Pediatric Nephrology
- Biomarkers
- Endocrinology
Background:
- Fibroblast growth factor 23 (FGF23) is a potential early biomarker for chronic kidney disease (CKD) progression.
- Existing data on the age dependency of FGF23 levels are inconsistent.
- This study investigates FGF23 levels in healthy children.
Purpose of the Study:
- To determine the age and sex dependency of intact FGF23 levels in healthy Polish children.
- To establish reference ranges for FGF23 in a pediatric population.
- To explore the correlation between FGF23 and estimated glomerular filtration rate (eGFR) in children.
Main Methods:
- Cross-sectional study of 121 healthy children aged 0-18 years.
- Measurement of intact FGF23 levels in serum.
- Assessment of kidney function using eGFR.
- Statistical analysis of FGF23 levels by age groups and gender.
Main Results:
- No statistically significant differences in FGF23 levels were found between age groups or genders.
- A trend towards higher FGF23 levels was observed in the youngest and oldest age groups.
- A significant negative correlation between eGFR and FGF23 was found in girls, but not in boys.
- No significant correlation between eGFR and FGF23 was observed within specific age groups.
Conclusions:
- FGF23 levels in the pediatric population are not dependent on age or sex.
- The findings provide a valuable reference point for clinical practice and future research on FGF23 in children.
- Further research is needed to clarify the relationship between FGF23, eGFR, and gender in pediatric populations.
Introduction:
It is believed that fibroblast growth factor 23 (FGF23) can become an early biomarker of chronic kidney disease progression. Data on FGF23 age dependency are inconsistent. We present the results of the cross-sectional study concerning FGF23 levels in healthy Polish children.
Material And Methods:
This study was conducted in 121 children aged 0-18 years. Kidney function and intact FGF23 levels in serum were assessed. Differences between age groups and according to gender were analysed.
Results:
The difference in FGF23 between age groups and according to gender was statistically insignificant. In the youngest and the oldest group, a trend to higher FGF23 levels was observed. FGF23 level in girls tended to be higher than boys, apart from the age group between 1 and 4 years. There was a negative correlation between eGFR and FGF23 (r = -0.26, p < 0.05) - strong in girls (r = -0.38, p < 0.05), but not in boys. In each age group, we found no significant correlation between eGFR and FGF23.
Conclusions:
Our study supports the evidence that the FGF23 level in paediatric population is not age or sex dependent. The results can serve as a reference point under clinical conditions and for other studies on the topic.
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