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Related Experiment Video

Updated: Oct 29, 2025

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Skin-on-a-chip models: General overview and future perspectives.

I Risueño¹, L Valencia¹, J L Jorcano¹

¹Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid (UC3M), 28911 Leganés (Madrid), Spain.

APL Bioengineering

|July 14, 2021

Summary

This summary is machine-generated.

Advancements in dynamic, vascularized 3D human skin models, known as skin-on-a-chip, offer more physiological testing than static models. These microfluidic platforms improve drug evaluation for cosmetics and pharmaceuticals.

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Last Updated: Oct 29, 2025

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Area of Science:

Biotechnology
Tissue Engineering
In Vitro Models

Background:

Static in vitro human skin models lack physiological accuracy for drug and cosmetic testing.
Dynamic perfusion and microfluidic systems are emerging for more representative skin modeling.

Purpose of the Study:

To review recent advances in dynamic, vascularized in vitro human skin models.
To discuss the development and application of skin-on-a-chip platforms.

Main Methods:

Review of literature on vascularized human skin equivalents (HSEs).
Analysis of transferred and in situ skin-on-a-chip approaches.
Discussion of cell introduction methods in microfluidic chips.

Main Results:

Skin-on-a-chip platforms enable physiological nutrient transport.
These models facilitate high-throughput, cost-effective drug toxicity and efficacy evaluations.
Advances include vascularized HSEs and both transferred and in situ chip designs.

Conclusions:

Dynamic skin-on-a-chip models represent a significant improvement over static in vitro systems.
These platforms hold promise for future applications in pharmaceutical and cosmetic testing.
Further research directions and current applications are presented.