Related Experiment Video
Updated: Oct 29, 2025

07:07
A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
12.7K
Melanoma mimicking atypical fibroxanthoma: Report of an unusual case
Yanqing Wang1,2, Ying Guo1
1Ackerman Academy of Dermatopathology, New York, New York, USA.
Journal of Cutaneous Pathology
|July 14, 2021
Abstract:
Melanoma may mimic a variety of skin lesions clinically and histopathologically, and presents diagnostic challenges. In this article, we describe a case of melanoma in an 89-year-old man with a very rare histopathologic presentation, namely the presence of pleomorphic and multinucleated giant cells with abundant cytoplasm, highly resembling an atypical fibroxanthoma. The differential diagnoses in conjunction with the findings in immunohistochemical study are also discussed.

