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The hemostatic and thrombotic complications of liver disease

Hannah Stowe McMurry1, Janice Jou2, Joseph Shatzel3,4

  • 1Divison of Internal Medicine, Oregon Health & Science University, Portland, OR, USA.

European Journal of Haematology
|July 14, 2021
PubMed

Hepatic cirrhosis leads to numerous hematologic derangements resulting in a complex and tenuously rebalanced hemostatic milieu. The utility of common hematologic tests including the INR and aPTT in assessing hemostatic and thrombotic risk in patients with cirrhosis is limited, and consensus on transfusion thresholds and proper management of thrombotic complications continues to evolve. This review summarizes the pathophysiology of key derangements of hemostasis including those of platelets, von Willebrand factor, pro- and anticoagulation factors, and fibrin. Additionally, the pathogenesis, consequences, optimal management, and prevention of major thrombotic and bleeding complications in cirrhosis arte discussed.

Keywords:
blood coagulationhemostasishumansliver cirrhosisthrombosis

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