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Self-Propelled Asymmetrical Nanomotor for Self-Reported Gas Therapy
Ludan Yue1, Kuikun Yang1, Junyan Li1
1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, 999078, P. R. China.
Small (Weinheim an Der Bergstrasse, Germany)
|July 14, 2021
Summary
This study introduces a novel nanomotor for targeted cancer gas therapy. The Au@MnO2 nanomotor delivers therapeutic gases deep into tumors and self-reports treatment efficacy, improving cancer treatment strategies.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapy
Background:
- Gas therapy offers high efficacy and biosafety for cancer treatment.
- Clinical application is limited by rapid gas diffusion and poor tissue penetration.
Purpose of the Study:
- To develop a self-propelled nanomotor for efficient deep-tumor delivery of therapeutic gases.
- To enable in situ monitoring of gas therapy's therapeutic process.
Main Methods:
- Fabrication of asymmetrical gold-manganese dioxide (Au@MnO2) nanomotors.
- Utilized catalytic conversion of H2O2 to O2 for propulsion into tumors.
- Incorporated a self-reporting mechanism using fluorescein isothiocyanate (FITC) activated by caspase-3.
Main Results:
- Au@MnO2 nanomotors demonstrated efficient propulsion into deep tumor tissues.
- Degradation of MnO2 shells released sulfur dioxide (SO2) prodrug within tumors.
- FITC fluorescence confirmed therapeutic efficacy and apoptosis via caspase-3 detection.
Conclusions:
- The developed Au@MnO2 nanomotors provide a promising platform for enhanced gas therapy in deep-seated tumors.
- The self-reporting capability allows real-time monitoring of therapeutic response.
- This approach offers significant advancements in nanomotor design for targeted cancer treatment.
