Related Experiment Video

Updated: Oct 29, 2025

Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production

Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production

Published on: June 2, 2023

Effects of Di-2-Ethylhexyl Phthalate on Central Nervous System Functions: A Narrative Review

Soheila Safarpour^1,2, Maryam Ghasemi-Kasman^3,4, Samaneh Safarpour⁵

¹Student Research Committee, Babol University of Medical Sciences, Babol, Iran.

Current Neuropharmacology

|July 14, 2021

Abstract

Background:

Phthalates are widely used in the plastics industry. Di-2-Ethylhexyl Phthalate (DEHP) is one of the most important phthalate metabolites that disrupt the function of endocrine glands. Exposure to DEHP causes numerous effects on animals, humans, and the environment. Low doses of DEHP increase neurotoxicity in the nervous system that has arisen deep concerns due to the widespread nature of DEHP exposure and its high absorption during brain development.

Objective:

In this review article, we evaluated the impacts of DEHP exposure from birth to adulthood on neurobehavioral damages. Then, the possible mechanisms of DEHP-induced neurobehavioral impairment were discussed.

Methodology:

Peer-reviewed articles were extracted through Embase, PubMed, and Google Scholar till the year 2021.

Results:

The results showed that exposure to DEHP during pregnancy and infancy leads to memory loss and irreversible nervous system damage.

Conclusion:

Overall, it seems that increased levels of oxidative stress and inflammatory mediators possess a pivotal role in DEHP-induced neurobehavioral impairment.

Keywords:

Endocrine disruptors di-2-ethylhexyl phthalate memory deficits neurobehavioral impairment neurotoxicity phthalates

More Related Videos

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

Related Concept Videos

Toxic Reactions: Overview

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

Local Anesthetics: Adverse Effects

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...

Articles linked to this work by shared authors, journal, and citation graph.

Radiation induces senescence in lymphatic endothelial cells (LECs) and murine tail lymphedema tissue, contributing to lymphedema progression.

Cell death & disease·2026

Co-administration of quercetin and NLRP3 inhibitor attenuates inflammation and oxidative stress in cuprizone-induced demyelination model.

Brain research bulletin·2026

Mechanistic Insights and Therapeutic Potential of MCC950 as a NLRP3 Inflammasome Inhibitor in Multiple Sclerosis: A Narrative Review.

Current reviews in clinical and experimental pharmacology·2026

Quercetin Improves Cognitive Function by Ameliorating Histopathological Changes and Inflammation in Di(2-ethylhexyl) Phthalate-Exposed Mice.

Brain sciences·2026

Endoplasmic Reticulum Stress in Spinal Cord Injury: Pathological Roles, Molecular Targets, and Emerging Treatments: A Systematic Review.

Molecular neurobiology·2026

Mesenchymal stem cells-derived exosomes and Kaempferol improve myelin repair via attenuating inflammation and oxidative stress in a cuprizone-induced demyelination model.

Stem cell research & therapy·2025

See all related articles