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A novel mouse model simulating transurethral laser vaporization prostatectomy.

Heng Zhang1, Ye Tian2, Bing Yang3

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|July 14, 2021
PubMed
Summary

Researchers developed a new mouse model for transurethral laser prostatectomy (TULP), a common BPH treatment. This model effectively simulates wound healing after prostate surgery, aiding future research into benign prostatic hyperplasia therapies.

Keywords:
animal modelbenign prostatic hyperplasiatransurethral resection of the prostate

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Area of Science:

  • Urology
  • Surgical Innovation
  • Animal Modeling

Background:

  • Benign prostatic hyperplasia (BPH) affects many elderly men, with transurethral laser prostatectomy (TULP) being a standard treatment for associated bladder outlet obstruction.
  • Existing animal models for post-prostatectomy wound repair have significant limitations, and a specific mouse model for TULP was previously unreported.

Purpose of the Study:

  • To establish and validate a novel mouse model for transurethral laser prostatectomy (TULP).

Main Methods:

  • Twelve Kunming mice underwent transurethral laser vaporization prostatectomy using a 200-μm thulium laser.
  • Prostatic urethra and bladder neck specimens were collected at 1, 3, 5, and 7 days post-surgery.
  • Hematoxylin-eosin (HE) staining and immunohistochemistry (uroplakin expression) were used to assess wound healing.

Main Results:

  • Absence of uroplakin (UPK)-positive urothelium and presence of necrotic tissue were observed at 1 day post-surgery.
  • Re-epithelialization was initiated by day 5, with a monolayer of UPK-positive urothelium.
  • Complete wound repair, indicated by multilayered UPK-positive urothelium, was evident by day 7.

Conclusions:

  • A feasible mouse model for TULP has been successfully established using a microcystoscope and a 200-μm thulium laser.
  • This model accurately reflects the timeline of urothelial wound healing following TULP.