Related Experiment Video
Updated: Oct 29, 2025
Comet Assay as an Indirect Measure of Systemic Oxidative Stress
Published on: May 22, 2015
Systemic oxidative stress biomarkers in patients with vitreomacular traction syndrome
Deniz Kilic1, Derya Kocer2, Ender Sırakaya3
1Department of Ophthalmology, Kayseri City Training and Research Hospital, Health Science University, Yakut Region, 3844 Street, House Number: 20/16, 38001, Kayseri, Turkey. dnz_kilic@hotmail.com.
Purpose:
To evaluate whether the systemic oxidative stress biomarkers increased in patients with vitreomacular traction syndrome (VMT).
Methods:
This study compared 25 patients diagnosed with VMT with 20 healthy controls. As a biomarker of systemic oxidative stress, malondialdehyde (MDA) was measured. Total oxidant status (TOS) and total antioxidant status (TAS) were measured to evaluate the systemic oxidant status.
Results:
Serum MDA values were significantly higher among the patients (p < 0.001). The ideal cut-off value for MDA was determined to be 22.1 µmol/L, with 80% sensitivity and 75% specificity. The between-group differences were not statistically significant for TOS or TAS (p = 0.326 and p = 0.698, respectively).
Conclusion:
Increased MDA levels suggest that systemic oxidative stress may play a role in VMT.
More Related Videos
14:25Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells
Published on: May 13, 2022
12:59Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage
Published on: February 15, 2020