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A Systematic Review of Depression and Anxiety in Adults with Pyoderma Gangrenosum
Meghan L McPhie1, Joshua Fletcher, Myrela O Machado
1Meghan L. McPhie, PhD, is Medical Student, Queen's University, School of Medicine, Kingston, Ontario, Canada. At the University of Toronto, Ontario, Joshua Fletcher, MD, is Family Medicine Resident, Division of Dermatology; Myrela O. Machado, MD, is Clinical Fellow, Division of Dermatology; Andre F. Carvalho, MD, PhD, is Associate Professor of Psychiatry, Department of Psychiatry; and Vincent Piguet, MD, PhD, is Director, Division of Dermatology. Afsaneh Alavi, MD, MSc, is Associate Professor, Department of Dermatology, Mayo Clinic, Rochester, Minnesota. Acknowledgments: Dr Alavi has been consultant for AbbVie, BI, Janssen, InflaRx, Novartis, UCB, and an investigator for BI and Castle Creek. The authors have disclosed no financial relationships related to this article. Submitted August 13, 2020; accepted in revised form October 28, 2020.
Objective:
To synthesize the available evidence on the prevalence and odds for anxiety and depression in adults with pyoderma gangrenosum (PG).
Data Sources:
Observational studies examining anxiety and depression in adults with PG were systematically searched using the MEDLINE, EMBASE, PsycINFO, and CINAHL databases from the inception of each database to March 11, 2020.
Study Selection:
Two authors independently screened references based on predetermined eligibility criteria.
Data Extraction:
Of the 244 articles identified, three met the eligibility criteria. Relevant data were extracted from included studies, and methodological quality was evaluated independently by two authors using the modified Newcastle-Ottawa Scale.
Data Synthesis:
Three observational studies comprising 183 participants with PG met the inclusion criteria. Estimated rates of depression in adults with PG ranged from 10% to 23%. None of the studies measured rates of anxiety.
Conclusions:
The current systematic review suggests that depression is a common psychological comorbidity in adults with PG. Additional research is required to further assess the psychological comorbidities in this population.
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