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In Vitro Model of Coronary Angiogenesis
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Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary

Barry R Palmer1,2, Melinda A Paterson1, Chris M Frampton1

  • 1Department of Medicine, Christchurch Heart Institute, University of Otago Christchurch, Christchurch, New Zealand.

Plos One
|July 14, 2021
PubMed

Insights

Vascular Endothelial Growth Factor-A (VEGF-A) levels and specific gene variants show prognostic value in coronary heart disease. Higher VEGF-A and certain genotypes may predict survival and collateral circulation development in patients.

Area of Science:

  • Cardiovascular Research
  • Genetics
  • Biomarker Discovery

Background:

  • Coronary artery disease (CAD) management benefits from understanding collateral circulation.
  • The vascular endothelial growth factor (VEGF) system is crucial for collateral vessel development.
  • Investigating VEGF-A and its gene variants as prognostic markers in CAD is important.

Purpose of the Study:

  • To assess the prognostic performance of circulating VEGF-A levels.
  • To evaluate three single nucleotide polymorphisms (SNPs) in the VEGFA gene.
  • To explore the association between VEGF-A, its genetic variants, and collateral circulation in a coronary cohort.

Main Methods:

  • Analysis of 1927 patients from the Coronary Disease Cohort Study (CDCS).
  • Genotyping for VEGFA SNPs: rs699947, rs2010963, and rs3025039.
  • Assay of plasma VEGF-A concentrations in a subgroup (n=550).

Main Results:

  • VEGF-A levels correlated with baseline heart rate.
  • rs3025039 genotype associated with collateral vessel perfusion (Rentrop classification) and natriuretic peptide levels.
  • Survival was independently associated with baseline VEGF-A levels and, in males, with rs699947 genotype.

Conclusions:

  • Circulating VEGF-A levels show potential as a prognostic biomarker in coronary heart disease.
  • VEGFA gene SNPs warrant further investigation as prognostic markers.
  • VEGF-A and its variants may indicate angiogenic potential influencing collateral circulation.
Abstract

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