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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
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Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression
Md Rezanur Rahman1,2, Tania Islam1, Md Shahjaman3
1Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh.
Briefings in Bioinformatics
|July 14, 2021
Summary
This study reveals shared gene expression patterns between COVID-19 and diabetes mellitus (DM). Identifying these commonalities could lead to personalized treatments for diabetic patients with COVID-19.
Area of Science:
- Genomics
- Molecular Biology
- Infectious Diseases
Background:
- COVID-19 severity is increased in patients with diabetes mellitus (DM).
- Understanding shared molecular mechanisms between COVID-19 and DM is crucial for effective treatment strategies.
Purpose of the Study:
- To identify common transcriptional signatures, regulators, and pathways in COVID-19 and DM.
- To explore molecular links between SARS-CoV-2 infection and diabetes.
Main Methods:
- Integrated human whole-genome transcriptomic datasets from COVID-19 and DM patients.
- Performed functional assessments using Gene Ontology (GO) and pathway analyses.
- Identified differentially expressed genes (DEGs) and transcription factors.
Main Results:
- Commonly upregulated and downregulated DEGs were identified in peripheral blood mononuclear cells (PBMCs) for both type 1 and type 2 diabetes.
- Shared transcriptional changes were observed in SARS-CoV-2 infected pancreas organoids and type 2 diabetes islets.
- RELA was predicted as a key transcription factor involved in shared gene upregulation in PBMCs and pancreas.
Conclusions:
- This study provides the first characterization of commonly dysregulated biological processes and pathways in COVID-19 and DM.
- Findings may inform the development of personalized treatments for COVID-19 patients with diabetes comorbidity.
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