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Updated: Jun 11, 2026

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Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
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Formative research to design an implementation strategy for a postpartum hemorrhage initial response treatment bundle
Meghan A Bohren1, Fabiana Lorencatto2, Arri Coomarasamy3
1Gender and Women's Health Unit, Centre for Health Equity, University of Melbourne School of Population and Global Health, 207 Bouverie St, Carlton, VIC, 3053, Australia. meghan.bohren@unimelb.edu.au.
Reproductive Health
|July 15, 2021
Summary
This study outlines the E-MOTIVE bundle protocol to improve postpartum hemorrhage (PPH) management. The formative phase will develop strategies for implementing this PPH care bundle in routine practice.
Area of Science:
- Implementation Science
- Maternal Health
- Clinical Interventions
Background:
- Postpartum hemorrhage (PPH) is a leading global cause of maternal mortality.
- Effective PPH management relies on early detection and adherence to evidence-based guidelines.
- Challenges in consistent guideline adherence necessitate innovative implementation strategies.
Purpose of the Study:
- To describe the protocol for the formative phase of the E-MOTIVE project.
- To design an implementation strategy for the E-MOTIVE clinical care bundle.
- To improve PPH detection and first-response management.
Main Methods:
- Utilizing behavior change (COM-B) and implementation science (TDF) frameworks.
- Employing qualitative interviews, surveys, systematic reviews, and design workshops.
- Triangulating data across diverse sources and countries (Kenya, Nigeria, South Africa, Sri Lanka, Tanzania).
Main Results:
- The formative phase protocol is detailed.
- Exploration of factors influencing PPH detection and management.
- Development of tailored implementation strategies through stakeholder engagement.
Conclusions:
- The protocol systematically guides the development of the E-MOTIVE implementation strategy.
- Focus on implementation planning supports future scalability and routine practice adoption.
- Aims to maximize trial validity and facilitate widespread E-MOTIVE bundle use.

