Related Experiment Video
Updated: Oct 28, 2025
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
18.1K
Disease course following High Disease Activity Status revealed patterns in SLE
Alberta Hoi1,2, Rachel Koelmeyer3, Julie Bonin3
1Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Level 5, Block E, Monash Medical Centre, 246 Clayton Road, Clayton, VIC, 3168, Australia. alberta.hoi@monash.edu.
Arthritis Research & Therapy
|July 15, 2021
Summary
High Disease Activity Status (HDAS) in systemic lupus erythematosus (SLE) often recurs and is linked to greater damage accrual. Achieving Lupus Low Disease Activity State (LLDAS) is crucial for better patient outcomes.
Area of Science:
- Rheumatology
- Immunology
- Systemic Lupus Erythematosus Research
Background:
- High Disease Activity Status (HDAS) is a critical concern in SLE management.
- Limited data exists on the long-term outcomes of SLE patients achieving Lupus Low Disease Activity State (LLDAS).
Purpose of the Study:
- To investigate the disease course and patterns of HDAS in a real-world SLE cohort.
- To explore the association between HDAS patterns and the risk of damage accrual.
Main Methods:
- Analysis of the Monash Lupus Cohort with at least 12 months of observation.
- Definition of HDAS (SLEDAI-2K ≥ 10) and HDAS episode (time to LLDAS).
- Examination of associations between HDAS patterns (recurrent, persistent) and damage accrual.
Main Results:
- 151 of 342 SLE patients experienced HDAS, with 76.2% having recurrent HDAS.
- Recurrent or Persistent HDAS was linked to younger age at diagnosis and increased renal, serositis, or neurological manifestations.
- Longer HDAS duration (>2 years) and multiple episodes (≥4) significantly increased the likelihood of damage accrual.
Conclusions:
- HDAS episodes exhibit variable courses, with recurrent and persistent patterns increasing damage risk.
- The duration and frequency of HDAS episodes are significant predictors of long-term damage.
- Achieving LLDAS is vital for mitigating damage and improving outcomes in SLE patients.
Related Concept Videos
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
147
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
147
01:26Nephrotic Syndrome II : Assessment and Medical Management
46
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
46
01:25Endocarditis II: Clinical Features of Infective Endocarditis
62
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
62
01:20Rheumatic Heart Disease IV: Nursing Management
85
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
85
01:26Stages of Infection
60.9K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
60.9K
01:23Rheumatic Heart Disease I: Introduction
133
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
133