Diagnostic test accuracy of ¹⁸F-FDG PET/CT for prediction of programmed death ligand 1 (PD-L1) expression in solid...

To investigate the predictive value of integrated 2-[¹⁸F]-fluoro-2-deoxy-d-glucose (¹⁸F-FDG) positron-emission tomography/computed tomography (PET/CT) for the prediction of programmed death ligand 1 (PD-L1) expression in solid tumours via a systematic review and meta-analysis.

The PubMed, Cochrane, and EMBASE databases, from the earliest available date of indexing through 31 October 2020, were searched for studies evaluating the diagnostic performance of ¹⁸F-FDG PET/CT for prediction of PD-L1 expression in solid tumours other than lung cancer.

Across seven studies (473 patients), the pooled sensitivity for ¹⁸F-FDG PET/CT was 0.75 (95% confidence interval [CI]: 0.65-0.82) without heterogeneity (I² = 47.2, p=0.08) and a pooled specificity of 0.73 (95% CI: 0.64-0.81) with heterogeneity (I² = 53.8, p=0.04). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 2.8 (95% CI: 2.1-3.7) and negative likelihood ratio (LR-) of 0.35 (95% CI: 0.26-0.47). The pooled diagnostic odds ratio (DOR) was 8 (95% CI: 5-13). Hierarchical summary receiver operating characteristic (ROC) curve and indicates that the area under the curve was 0.80 (95% CI: 0.77-0.84).

The current meta-analysis showed a moderate sensitivity and specificity of ¹⁸F-FDG PET/CT for the prediction of PD-L1 expression in solid tumours. At present, the literature regarding the use of ¹⁸F-FDG PET/CT for the prediction of PD-L1 expression in solid tumours still limited; thus, further large multicentre studies would be necessary to substantiate the diagnostic accuracy of ¹⁸F-FDG PET/CT for prediction of PD-L1 expression in solid tumours.