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Coronavirus disease 2019 in children

Emily R Levy1,2, Jennifer Blumenthal3,4, Kathleen Chiotos5,6

  • 1Division of Pediatric Infectious Diseases.

Current Opinion in Infectious Diseases
|July 15, 2021
PubMed

Insights

Children with coronavirus disease 2019 (COVID-19) typically experience mild infections, but severe illness can occur. Ongoing research focuses on pediatric transmission, treatments, and vaccine development for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Area of Science:

  • Pediatric infectious diseases
  • Viral epidemiology
  • Public health

Background:

  • Coronavirus disease 2019 (COVID-19) presents differently in children compared to adults.
  • Understanding pediatric-specific clinical features, transmission, and outcomes is crucial.
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research in children is evolving.

Purpose of the Study:

  • To review recent pediatric studies on COVID-19.
  • To discuss pediatric considerations for disease transmission, therapies, and vaccination.
  • To synthesize current knowledge on COVID-19 in the pediatric population.

Main Methods:

  • Review of recent pediatric studies and clinical trials.
  • Analysis of epidemiological data on SARS-CoV-2 in children.
  • Synthesis of information on COVID-19 management and prevention in pediatric populations.

Main Results:

  • Most children experience asymptomatic or mild COVID-19 infections.
  • Severe COVID-19 is infrequently reported in pediatric cases.
  • Adult treatment protocols offer insights, but pediatric-specific data is needed.
  • Comorbidities influence severe outcomes; transmission dynamics require further study.
  • Pediatric vaccine trials are underway.

Conclusions:

  • Children generally recover well from acute COVID-19.
  • Further research is needed on pediatric SARS-CoV-2 transmission, especially in schools.
  • Evaluating pediatric vaccine candidates is a priority for future prevention strategies.
Abstract

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