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Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control.
Yue Deng1, Guorui Deng1, Justin L Grobe2,3,4
1Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, United States.
Frontiers in Physiology
|July 15, 2021
Summary
Obesity links to sympathetic overdrive, a cardiovascular disease risk. This review explores hypothalamic G-protein coupled receptors (GPCRs) and their role in metabolic and cardiovascular regulation.
Area of Science:
- Neuroscience
- Cardiovascular Science
- Endocrinology
Background:
- Obesity is linked to sympathetic overdrive, a key risk factor for cardiovascular diseases like hypertension and heart failure.
- While central obesity mechanisms are increasingly understood, their impact on cardiovascular regulation remains unclear.
Purpose of the Study:
- To review G-protein coupled receptors (GPCRs) in the hypothalamus involved in metabolic homeostasis and cardiovascular function.
- To discuss the downstream signaling pathways and molecular mediators of these GPCRs.
Main Methods:
- Literature review of studies on hypothalamic nuclei, GPCRs, and their roles in metabolism and cardiovascular control.
- Analysis of molecular mechanisms linking hypothalamic signaling to sympathetic activity.
Main Results:
- Hypothalamic GPCRs activated by hormones, neuropeptides, and neurotransmitters regulate appetite, metabolic homeostasis, and sympathetic cardiovascular control.
- Specific GPCRs and hypothalamic nuclei are identified as crucial links between metabolic state and cardiovascular function.
Conclusions:
- Understanding hypothalamic GPCR signaling is vital for addressing obesity-related cardiovascular risks.
- Targeting these pathways may offer novel therapeutic strategies for metabolic and cardiovascular disorders.
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