Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

HIV vaccines induce CD8<sup>+</sup> T cells with low antigen receptor sensitivity.

Science (New York, N.Y.)·2023

Same author

Improved the slow digestion property of maize starch using partially β-amylolysis.

Food chemistry·2014

Same author

Blend-modification of soy protein/lauric acid edible films using polysaccharides.

Food chemistry·2014

Same author

Structure and physicochemical properties of octenyl succinic esters of sugary maize soluble starch and waxy maize starch.

Food chemistry·2014

Same author

[Effects of left renal vein division on postoperative renal function during open repair of abdominal aortic aneurysm].

Zhonghua yi xue za zhi·2014

Same author

Association of four insulin resistance genes with type 2 diabetes mellitus and hypertension in the Chinese Han population.

Molecular biology reports·2014

Search research articles

Related Experiment Video

Updated: Oct 28, 2025

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs

Published on: December 13, 2019

Development of a Bioartificial Vascular Pancreas.

Edward X Han¹, Juan Wang^2,3, Mehmet Kural^2,3

¹Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.

Journal of Tissue Engineering

|July 15, 2021

Summary

The BioVascular Pancreas (BVP) offers a novel solution for type 1 diabetes treatment by using a vascular graft to deliver oxygen to transplanted pancreatic islets, improving survival and function.

Keywords:

Cell-based therapeutics Islet transplantation Tissue engineering Type 1 diabetes Vascular graft

More Related Videos

A System for ex vivo Culturing of Embryonic Pancreas

A System for ex vivo Culturing of Embryonic Pancreas

Published on: August 27, 2012

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Related Experiment Videos

Last Updated: Oct 28, 2025

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs

Published on: December 13, 2019

A System for ex vivo Culturing of Embryonic Pancreas

A System for ex vivo Culturing of Embryonic Pancreas

Published on: August 27, 2012

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Area of Science:

Regenerative Medicine
Biomaterials Science
Endocrinology

Background:

Pancreatic islet transplantation is a potential treatment for type 1 diabetes.
Current transplantation methods face challenges with insufficient oxygen supply, leading to islet loss.
Scaling up islet transplantation for human application is hindered by oxygen diffusion limitations.

Purpose of the Study:

To develop and evaluate a novel vascular scaffold for pancreatic islet transplantation, termed the BioVascular Pancreas (BVP).
To overcome oxygenation limitations associated with traditional islet transplantation methods.
To assess the efficacy and scalability of the BVP for treating type 1 diabetes.

Main Methods:

Islets were seeded onto an acellular vascular graft using fibrin hydrogel, creating the BVP.
The BVP was designed to allow oxygenated arterial blood flow through the graft lumen to supply islets.
In silico simulations, in vitro bioreactor experiments, and in vivo implantation in nude rats and pigs were conducted.

Main Results:

The BVP design demonstrated adequate islet survivability and avoidance of hypoxia in simulations and bioreactor studies.
Implantation in rats restored near-normoglycemia for 90 days and showed robust host vascular infiltration.
Pilot studies in pigs indicated the scalability of the BVP technology.

Conclusions:

The BioVascular Pancreas (BVP) effectively addresses oxygenation challenges in pancreatic islet transplantation.
The BVP shows promise as a durable and scalable solution for type 1 diabetes treatment.
This innovative tissue engineering approach may offer a pathway to cure type 1 diabetes through islet transplantation.