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Updated: Oct 28, 2025

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Combination Therapies for HPV-Associated Malignancies.
Claire Smalley Rumfield1, Jeffrey Schlom1, Caroline Jochems1
1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Human papillomavirus (HPV) vaccines prevent infections but do not treat existing HPV-associated cancers. New combination therapies are in development to improve survival and quality of life for patients with these malignancies.
Area of Science:
- Oncology
- Virology
- Public Health
Background:
- Human papillomavirus (HPV) causes nearly all cervical cancers and a significant portion of head and neck cancers, contributing to global cancer burden.
- Prophylactic HPV vaccines like Gardasil® and Cervarix® have reduced HPV infections but do not treat established HPV-related malignancies.
- Effective therapies are crucial for improving patient outcomes in HPV-associated cancers.
Purpose of the Study:
- To review emerging combination therapies for HPV-associated malignancies.
- To highlight advancements in treating established HPV-related cancers.
Main Methods:
- Literature review of clinical trials and research on HPV-associated malignancy treatments.
- Analysis of new therapeutic combinations in development.
Main Results:
- Established HPV infections and resulting cancers require treatment beyond prophylactic vaccination.
- Several novel combination therapy strategies are under clinical investigation.
Conclusions:
- While HPV vaccines are effective preventatives, therapeutic options for existing HPV-associated malignancies are essential.
- Ongoing research into combination therapies offers hope for improved patient survival and quality of life.
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Published on: April 20, 2018
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
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