Related Experiment Video
Updated: Oct 28, 2025
The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
Relationship Between Ultrasound Features and Ki-67 Labeling Index of Soft Tissue Sarcoma
Pingping Wang1, Hai Li2, Yu Hu1
1Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Objectives:
To explore the relationship between ultrasound (US) features and Ki-67 labeling index (LI) of soft tissue sarcoma (STS).
Methods:
Forty-six patients with 47 STS lesions, between September 2014 and April 2020, were enrolled in the study. Point-biserial correlation analysis and Spearman's correlation analysis were utilized to examining the relationship between the US features and the Ki-67 LI of STS. The differences of US features between high and low Ki-67 proliferation groups were statistically analyzed by independent t test, Wilcoxon rank-sum test, and Fisher's exact test. The optimal cut-off points of US features revealing significant differences were estimated by the maximum Youden index.
Results:
A moderate correlation between the vascular density grade and the Ki-67 LI (ρ = 0.409, P = 0.004) was found in this study. In addition, other ultrasound features were irrelevant to the Ki-67 LI. The cut-off for differentiating low- and high-proliferation groups was grade II according to the best Youden index. The area under receiver operating characteristic (ROC) curve was 0.74 (p = 0.011) with a sensitivity of 60.6% and specificity of 78.6%.
Conclusions:
Only the vascular density grade of STS had a weak positive correlation with Ki-67 LI, and might be capable of predicting the proliferation of STS. Other ultrasonographic features of STS such as shape and tumor margin have no correlation with Ki-67 LI.
