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Comparative analysis of microRNA expression profiles in the colons of specific pathogen-free mice and germ-free mice
Ayako Aoki1,2, Reiji Aoki2, Madoka Yatagai1
1Department of Food and Nutrition, Faculty of Human Sciences and Design, Japan Women's University, Bunkyo-ku, Tokyo, Japan.
Abstract:
MicroRNAs play an important role in microbiota-host crosstalk. In this study, we compared microRNA expression in whole colons of specific pathogen-free mice and germ-free mice. Forty-eight microRNAs were differentially expressed by more than 2-fold. Gene ontology analysis of the predicted mRNA targets revealed that the majority of the most significant gene ontology terms were related to GTPases and nerves.
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