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Granulomatous dermatitis following measles, mumps, and rubella vaccination

Quentin Samaran1, Evangéline Clark1, Léo-Paul Secco1

  • 1Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France.

Pediatric Dermatology
|July 15, 2021
PubMed

Insights

Granulomatous reactions after vaccines are known, but this is the first report of a granuloma annulare-like skin issue after the measles, mumps, and rubella (MMR) vaccine in a child.

Area of Science:

  • Dermatology
  • Vaccinology
  • Pediatrics

Background:

  • Vaccine administration is associated with various cutaneous reactions.
  • Granulomatous dermatitis has been documented following several vaccine types.
  • However, specific reports linking the measles, mumps, and rubella (MMR) vaccine to granulomatous skin conditions are absent.

Observation:

  • A 3-year-old boy developed a distinct skin reaction post-MMR vaccination.
  • The observed reaction presented as a granuloma annulare-like eruption.
  • This case highlights a potential, previously unreported, cutaneous side effect of the MMR vaccine.

Findings:

  • This study documents the first known instance of granuloma annulare-like reaction following the MMR vaccine.
  • The findings suggest a potential association between MMR vaccination and specific granulomatous skin manifestations in children.
  • Further investigation is warranted to understand the immunologic mechanisms involved.

Implications:

  • This report expands the understanding of potential vaccine-related dermatoses.
  • It may prompt increased vigilance for similar reactions in pediatric populations post-MMR vaccination.
  • Clinicians should consider MMR vaccine as a potential trigger for granuloma annulare-like eruptions.
Keywords:
and rubella vaccinedermatopathologydrug reactiongranulomagranulomatous dermatitishistologymeaslesmumpsvaccination

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