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Safety and efficacy of remimazolam compared with propofol in induction of general anesthesia

Guangrong Dai1, Lili Pei2, Fenyu Duan1

  • 1Department of Anesthesiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, China.

Minerva Anestesiologica
|July 15, 2021
PubMed
Abstract

Insights

Remimazolam offers a safe and effective alternative for general anesthesia induction, demonstrating comparable efficacy to propofol with fewer adverse events like injection site pain.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Remimazolam is an ultrashort-acting benzodiazepine anesthetic.
  • Propofol is a widely used intravenous anesthetic.
  • Limited comparative data exists for anesthesia induction.

Purpose of the Study:

  • To evaluate remimazolam's superiority over propofol for general anesthesia induction.
  • To compare efficacy and safety profiles of remimazolam and propofol.

Main Methods:

  • A randomized trial involving 189 ASA I/II patients.
  • Four groups: remimazolam (0.2, 0.3, 0.4 mg/kg) and propofol.
  • Efficacy measured by successful induction without rescue sedation; safety by absence of severe adverse events.

Main Results:

  • Remimazolam groups showed high success rates (89-100%) comparable to propofol (100%).
  • Lower hypotension rates observed with lower remimazolam doses (R1: 13%, R2: 24%) versus propofol (44%).
  • No injection site pain reported with remimazolam, unlike propofol (27%).

Conclusions:

  • Remimazolam is a safe and effective option for anesthesia induction in ASA I/II patients.
  • Remimazolam demonstrates a favorable safety profile with reduced adverse effects compared to propofol.

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