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Genome Sequences of Measles Virus D4 and D8 Genotypes from India

Divya R Bhattad1, Madhukar B Kamble1, Sunil R Vaidya1

  • 1Virus Registry and Virus Repository Group, ICMR National Institute of Virology, Pune, India.

Microbiology Resource Announcements
|July 15, 2021
PubMed

Insights

Measles virus genomes from Indian children were sequenced and analyzed. The study identified specific lineages of measles virus D4 and D8 circulating in India.

Area of Science:

  • Virology
  • Genomics
  • Epidemiology

Background:

  • Measles remains a significant public health concern globally.
  • Understanding the genetic diversity of measles virus is crucial for effective control strategies.

Purpose of the Study:

  • To sequence and phylogenetically analyze measles virus genomes from Indian pediatric patients.
  • To identify circulating measles virus lineages in India between 2006 and 2017.

Main Methods:

  • Whole-genome sequencing of 15 measles virus isolates from Indian children.
  • Phylogenetic analysis incorporating 143 Indian and global measles virus genomes.

Main Results:

  • Sequencing of 15 measles virus genomes from patients in India.
  • Phylogenetic analysis confirmed the presence of two distinct lineages within the D4 genotype and three distinct lineages within the D8 genotype of measles virus in India.

Conclusions:

  • The study provides insights into the genetic makeup of measles virus circulating in India.
  • Reconfirmation of specific D4 and D8 lineages highlights the importance of ongoing genomic surveillance for measles control.

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