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Multimarker profiling identifies protective and harmful immune processes in heart failure: findings from BIOSTAT-CHF
George Markousis-Mavrogenis1, Jasper Tromp1,2,3, Wouter Ouwerkerk2,4
1Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, TheNetherlands.
Cardiovascular Research
|July 15, 2021
Summary
Investigating immune processes in heart failure (HF) revealed that T-cell costimulation positively impacts mortality, while interferon-gamma responses negatively affect outcomes. This study identifies potential therapeutic targets for HF treatment.
Area of Science:
- Immunology
- Cardiology
- Biomarker Discovery
Background:
- Heart failure (HF) treatment is challenged by poorly understood inflammatory pathways.
- Novel immunomodulatory interventions are needed to improve HF outcomes.
Purpose of the Study:
- To investigate associations between immune process activation and patient outcomes in heart failure (HF).
- To identify potential therapeutic targets within these immune processes for HF.
Main Methods:
- Analyzed 355 biomarkers in 2022 HF patients and a validation cohort (n=1691).
- Classified biomarkers into biological processes using gene ontology.
- Used principal component analysis to derive weighted scores for immune processes.
- Assessed associations with 2-year all-cause mortality.
Main Results:
- Identified 64 unique immune-related processes; 19 were associated with mortality.
- 'T-cell costimulation' showed a positive association with mortality.
- 'Response to interferon-gamma' demonstrated a negative association with mortality.
- Inducible costimulator ligand, CD28, CD70, and TNFSF14 identified as potential targets within T-cell costimulation.
Conclusions:
- Different immune processes have opposing effects (protective vs. harmful) in HF.
- Findings suggest novel therapeutic targets for HF by modulating immune responses.
- Provides a foundation for future research on inflammation in HF.
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