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Questions about COVID-19 associated coagulopathy: possible answers from the viscoelastic tests

Vittorio Pavoni1, Lara Gianesello2, Maddalena Pazzi1

  • 1Emergency Department and Critical Care Area, Anesthesia and Intensive Care Unit, Santa Maria Annunziata Hospital, Bagno a Ripoli, Florence, Italy.

Journal of Clinical Monitoring and Computing
|July 15, 2021
PubMed

Insights

COVID-19 associated coagulopathy (CAC) presents unique clotting issues. Viscoelastic tests (VETs) offer dynamic insights into CAC, aiding clinicians in identifying hypercoagulable and hypofibrinolysis states in severe cases.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Abnormal coagulation is common in COVID-19, correlating with prognosis.
  • COVID-19 associated coagulopathy (CAC) involves a high risk of thromboembolism.
  • Viscoelastic tests (VETs) provide dynamic clot formation data in critical care.

Purpose of the Study:

  • To elucidate the characteristics of COVID-19 associated coagulopathy (CAC).
  • To explore the utility of viscoelastic tests (VETs) in understanding CAC.
  • To address unanswered questions regarding CAC through VETs analysis.

Main Methods:

  • Analysis of viscoelastic tests (VETs) data.
  • Utilizing thromboelastometry (ROTEM), thromboelastography (TEG), and Quantra Hemostasis Analyzer.
  • Reviewing studies on COVID-19 associated coagulopathy (CAC).

Main Results:

  • VETs provide dynamic insights into clot formation and dissolution in COVID-19 patients.
  • VETs can identify hypercoagulable and hypofibrinolysis states in severe COVID-19.
  • VETs offer valuable information for managing CAC.

Conclusions:

  • Viscoelastic tests are crucial for understanding the complex coagulopathy in COVID-19.
  • Further research using VETs is needed to fully characterize CAC.
  • VETs aid in identifying prothrombotic states associated with severe COVID-19.

Keywords:
COVID-19CoagulopathyThromboembolic eventsViscoelastic tests

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