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Neonatal hypertrophic cardiomyopathy: a case report and family study
R G Weintraub1, M J Swinburn, L Lee
1Department of Cardiology, Prince of Wales Children's Hospital, Randwick, New South Wales, Australia.
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Infant hypertrophic obstructive cardiomyopathy (HOCM) in a diabetic mother
Area of Science:
- Neonatal cardiology
- Pharmacology
- Genetics
Background:
- Infants of diabetic mothers are at risk for congenital heart defects.
- Neonatal hypertrophic obstructive cardiomyopathy (HOCM) can be severe and life-threatening.
- Familial hypertrophic cardiomyopathy (HCM) has a genetic component.
Abstract:
An infant of a diabetic mother is described with severe neonatal hypertrophic obstructive cardiomyopathy. Commencement of regular intravenous propranolol was associated with marked clinical improvement. Long-term oral propranolol was continued and at 12 months of age there was complete resolution of the cardiomyopathy. Familial hypertrophic cardiomyopathy hypertrophy was present in two other generations of this family. The results of family screening and tissue typing are presented, with the suggestion that tissue typing may be a useful tool in the assessment of doubtful cases in certain affected families.