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Protective Effect of Photobiomodulation on Denervated and Crushed Muscle

Shimon Rochkind1, Mara Almog1

  • 1Research Center for Nerve Reconstruction, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Photobiomodulation, Photomedicine, and Laser Surgery
|July 15, 2021
PubMed
Abstract

No abstract available in PubMed .

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
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