Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

2.7K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.7K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

2.8K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.8K
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

3.4K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
3.4K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

881
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
881
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.4K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.4K
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.9K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to Siddiqui et al., Godbout et al., and to Chang and Mao.

American journal of respiratory and critical care medicine·2026
Same author

Asthma exacerbation profile of benralizumab for severe eosinophilic asthma (the BenRex study): a multicentre, prospective cohort study.

The Lancet. Respiratory medicine·2026
Same author

Application of T2 biomarkers to support steroid stewardship in severe asthma-a retrospective cohort study.

The journal of allergy and clinical immunology. In practice·2026
Same author

Dupilumab sustains efficacy despite LABA and ICS withdrawal in patients with asthma: A post hoc analysis.

The journal of allergy and clinical immunology. In practice·2026
Same author

Clinical phenotyping improves choices of biologics in asthma - Authors' reply.

Lancet (London, England)·2026
Same author

Development and Validation of the Risk of Exacerbation in Severe Asthma (RESA) Model.

The journal of allergy and clinical immunology. In practice·2026

Related Experiment Video

Updated: Oct 28, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.1K

Workup of Severe Asthma.

Simon Couillard1, David J Jackson2, Michael E Wechsler3

  • 1Respiratory Medicine Unit and Oxford Respiratory NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, England; Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.

Chest
|July 15, 2021
PubMed
Summary

This study evaluates severe asthma management. Biomarkers like blood eosinophil counts and fractional exhaled nitric oxide aid in identifying ICS-resistant type 2 airway inflammation for targeted therapies.

Keywords:
Fenoadherenceairwaysasthmabiomarkerseosinophilsexacerbationsmultidisciplinary teamsevere asthmatype 2 inflammation

More Related Videos

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

40.7K
Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

1.3K

Related Experiment Videos

Last Updated: Oct 28, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.1K
Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

40.7K
Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

1.3K

Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Difficult-to-control asthma requires advanced therapeutic options.
  • High-dose inhaled corticosteroids (ICS) and controller therapies are often insufficient.
  • Accurate diagnosis and phenotyping are crucial for effective asthma management.

Purpose of the Study:

  • To review the clinical assessment of patients with suspected severe asthma.
  • To discuss factors contributing to poor asthma control.
  • To explore how biomarkers assist in disease investigation and stratification.

Main Methods:

  • Multidisciplinary approach including diagnosis confirmation and adherence assessment.
  • Evaluation of contributing comorbidities and confounding factors.
  • Stratification of asthma phenotype using spirometry and biomarkers (blood eosinophil count, fractional exhaled nitric oxide).

Main Results:

  • Biomarkers identify ICS-resistant type 2 airway inflammation or airflow obstruction as drivers of poor control.
  • Lack of inflammation evidence suggests alternative causes like infection or non-asthma conditions.
  • The patient presented with severe asthma and ICS-resistant type 2 airway inflammation.

Conclusions:

  • Objective evidence of inflammation, not just symptoms, should guide steroid use.
  • Targeted treatment approaches are necessary for each asthma phenotype.
  • Further advanced therapeutic options will be considered for ICS-resistant severe asthma.