Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pan-cancer single-cell atlas uncovers the role of sex hormones and chromosomes in sex-divergent reprogramming of the tumor microenvironment.

Cell communication and signaling : CCS·2026
Same author

Design of active pharmaceutical ingredient-ionic liquids for enhanced delivery to skin.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Fabrication of Microneedle Patches by Suspension Casting of Drugs in Organic Solvents.

Pharmaceutics·2026
Same author

Intelligent mobile health management for the risk of gastrointestinal bleeding in anticoagulated patients with cardiovascular disease.

Revista da Escola de Enfermagem da U S P·2026
Same author

Daily activity patterns from wearable accelerometry predict physical frailty and concern about falling.

NPJ digital medicine·2026
Same author

TROP2 as a promising therapeutic target in lung cancer: Current clinical trial landscape and future directions.

Pulmonary pharmacology & therapeutics·2026

Related Experiment Video

Updated: Oct 28, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.8K

Development of a thermostable oxytocin microneedle patch.

Yasmine Gomaa1, Chandana Kolluru2, Mikolaj Milewski3

  • 1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 15, 2021
PubMed
Summary

A novel microneedle patch delivers oxytocin effectively, offering a thermostable, easy-to-use alternative to injections. This innovation improves access to essential postpartum hemorrhage medication, especially in resource-limited settings.

Keywords:
Microneedle patchOxytocinPeptide hormone stabilityPostpartum hemorrhageThermostable formulationTransdermal drug delivery

More Related Videos

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.6K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.4K

Related Experiment Videos

Last Updated: Oct 28, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.8K
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.6K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.4K

Area of Science:

  • Obstetrics and Gynecology
  • Materials Science and Engineering
  • Pharmaceutical Sciences

Background:

  • Oxytocin is crucial for labor induction and managing postpartum hemorrhage.
  • Current injectable oxytocin requires refrigeration, limiting its accessibility in developing countries and during home births.
  • There is a need for a stable, easily administered oxytocin formulation.

Purpose of the Study:

  • To develop a thermostable microneedle (MN) patch for rapid, simplified oxytocin delivery.
  • To assess the stability and efficacy of oxytocin delivered via MNs compared to conventional methods.

Main Methods:

  • Stainless steel MN arrays were coated with oxytocin (10 IU, 16.8 μg).
  • Excipients including polyacrylic acid, trehalose, citrate buffer, and ethanol were tested for oxytocin stabilization.
  • Stability was evaluated at 40°C and 75% relative humidity for up to 12 months.
  • Oxytocin release into skin was measured within 1-5 minutes post-insertion.

Main Results:

  • Polyacrylic acid stabilized oxytocin for 2 months at 40°C/75% RH with no significant loss.
  • MNs with trehalose formulations retained 75% oxytocin potency for 12 months at 40°C under desiccated conditions.
  • Commercial Pitocin® potency reduced to 35% under the same conditions.

Conclusions:

  • Microneedle patches offer a promising, thermostable alternative for oxytocin administration.
  • This technology can simplify logistics and improve access to oxytocin, particularly in resource-limited settings.
  • Further development could enhance the use of oxytocin for maternal care globally.