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Impact of Intravenously Injected Contrast Agent on Bone Mineral Density Measurement in Dual-Source Dual-Energy CT
Vitali Koch1, Moritz H Albrecht1, Leon D Gruenewald1
1Division of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Academic Radiology
|July 16, 2021
Summary
Intravenously injected contrast agents do not significantly affect bone mineral density (BMD) assessment using dual-source dual-energy CT. This allows for accurate opportunistic BMD evaluation during tumor staging, potentially reducing radiation exposure.
Area of Science:
- Radiology
- Medical Imaging
- Bone Densitometry
Background:
- Dual-source dual-energy CT (DSCT) is increasingly used for tumor staging.
- Accurate bone mineral density (BMD) assessment is crucial for diagnosing osteoporosis and managing bone health.
- Evaluating the impact of contrast agents on BMD measurements in DSCT is important for optimizing imaging protocols.
Purpose of the Study:
- To evaluate the influence of intravenously injected contrast agents on BMD assessment using DSCT.
- To compare BMD measurements from unenhanced and contrast-enhanced DSCT scans of the lumbar spine.
Main Methods:
- Retrospective analysis of 1,031 patients undergoing DSCT for tumor staging.
- Phantomless volumetric BMD assessment of lumbar spine trabecular bone using dedicated postprocessing software.
- Comparison of BMD values from unenhanced and contrast-enhanced (portal venous phase) scans using correlation and agreement analyses.
Main Results:
- Mean BMD values were similar between unenhanced (115.53 ± 37.23 mg/cm³ ) and contrast-enhanced (116.10 ± 37.78 mg/cm³ ) DSCT.
- No significant difference (p = 0.44) was found between the two phases.
- High correlation (r = 0.971) and excellent agreement were observed between unenhanced and contrast-enhanced BMD measurements.
Conclusions:
- Portal venous phase DSCT enables accurate opportunistic BMD assessment of lumbar spine trabecular bone.
- DSCT offers flexibility for BMD evaluation in routine clinical practice.
- Utilizing contrast-enhanced DSCT for BMD assessment can potentially reduce radiation exposure by eliminating the need for separate osteodensitometry scans.
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