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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

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The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese

Zhiliang Zhang1,2, Chao Chang1, Yuxin Zhang2

  • 1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, 450052, Henan, China.

Scientific Reports
|July 16, 2021
PubMed

Insights

Low selenium levels are linked to a higher risk of death in Chinese heart failure patients. This study highlights the importance of monitoring selenium status for better heart failure prognosis.

Area of Science:

  • Cardiology
  • Nutritional Science
  • Clinical Research

Background:

  • Selenium (Se) deficiency's impact on heart failure (HF) prognosis in Chinese patients remains unclear.
  • Understanding this association is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the relationship between serum Se levels and clinical outcomes in Chinese patients with HF.
  • To determine if lower Se levels correlate with increased mortality or rehospitalization in HF patients.

Main Methods:

  • Retrospective study including 411 Chinese patients with HF who underwent serum Se examination.
  • Patients were stratified into quartiles based on serum Se concentrations.
  • Cox proportional hazard models were used to analyze the association between Se levels and outcomes (all-cause mortality, HF rehospitalization).

Main Results:

  • The mean serum Se level was 68.3 ± 27.7 µg/L.
  • Patients in the lowest Se quartile (17.40-44.35 µg/L) showed a significantly increased risk of all-cause mortality (adjusted hazard ratio: 2.32; 95% CI: 1.43-3.77; Ptrend = 0.001) compared to the highest quartile.
  • No significant differences in baseline characteristics were observed between the four Se quartiles.

Conclusions:

  • Lower serum Se levels are significantly associated with an increased risk of all-cause mortality in Chinese patients with heart failure.
  • Monitoring and potentially supplementing selenium may be beneficial for improving the prognosis of heart failure patients.
  • Further research is warranted to explore the therapeutic implications of selenium status in heart failure management.

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