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Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Oct 28, 2025

Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype

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Uncovering adagrasib resistance

¹Nature Reviews Clinical Oncology, . nrclinonc@nature.com.

Nature Reviews. Clinical Oncology

|July 16, 2021

Summary

No abstract available in PubMed .

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