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Effects of ethanol on acetylcholine and GABA release: differences in the role of potassium
R Strong1, C Rehwaldt, W G Wood
1Geriatric Research, Education, and Clinical Center, VA Medical Center, St. Louis, Missouri.
Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement
|January 1, 1987
Abstract:
Ethanol inhibited electrically stimulated [3H]ACh release from cortical brain slices, but not when release was stimulated by high potassium. In contrast, ethanol was ineffective on electrically stimulated release of [14]GABA from cortical brain slices, but inhibited potassium-induced release. Ethanol also significantly inhibited potassium-stimulated [14C]GABA release from cortical synaptosomes. These data suggest that ethanol selectively inhibits GABA release from neurons by a specific effect on potassium conductance, and inhibits ACh release by a selective effect on Na+ conductance.