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Updated: Oct 28, 2025

Microfluidics in Assessing Platelet Function
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Platelet Function Analysis by Flowcytometry in Thrombocytopenic Trauma Patients.

Tapasyapreeti Mukhopadhyay1, Arulselvi Subramanian1, Venencia Albert1

  • 1Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, AIIMS, New Delhi, India.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
|July 16, 2021
PubMed
Summary

Platelet dysfunction is common in trauma patients with low platelets, but it shows only a weak link to acute traumatic coagulopathy. Further research is needed to fully understand platelet function

Keywords:
HemostasisPlatelet activationPlatelet aggregationPlatelet dysfunction

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Area of Science:

  • Hematology
  • Trauma Research
  • Coagulation Science

Background:

  • Hemostasis relies on adequate platelet quantity and function.
  • Platelet function in trauma-induced thrombocytopenia is under-explored.
  • The role of platelet dysfunction in acute traumatic coagulopathy requires investigation.

Purpose of the Study:

  • To investigate platelet activation and aggregation in thrombocytopenic trauma patients.
  • To explore the association between platelet dysfunction and acute traumatic coagulopathy.
  • To determine the impact of platelet dysfunction on clinical outcomes, including mortality.

Main Methods:

  • Blood samples from 70 thrombocytopenic trauma patients were analyzed before platelet transfusion.
  • Flow cytometry was used to assess platelet activation and aggregation.
  • In-hospital mortality was the primary outcome measure.

Main Results:

  • Platelet dysfunction was identified in 57.1% of patients.
  • A weak inverse correlation was found between activated platelets and activated partial thromboplastin time (APTT).
  • Platelet activation showed a weak association with coagulopathy, with limited predictive value for mortality.

Conclusions:

  • Platelet dysfunction is prevalent in trauma patients with thrombocytopenia.
  • The contribution of platelet dysfunction to the pathogenesis of acute traumatic coagulopathy appears limited.
  • Further research is warranted to elucidate the precise role of platelets in trauma-induced coagulopathy.