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Naloxone elicits dose-dependent changes in alcohol-induced increases in endogenous dopamine release from rat striatum
R B Holman1, B M Snape, P S Widdowson
1Dept. of Physiology & Biochemistry, University of Reading, Berks., U.K.
Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement
|January 1, 1987
Abstract:
These experiments examined the effects of naloxone on alcohol-induced changes in striatal concentrations of DOPAC and HVA, on endogenous dopamine release from striatum in vitro, and on duration of sleep time in vivo. The results emphasize the role of opioid peptides in alcohol's effects on dopaminergic function and on behaviour.