Related Experiment Video
Updated: Oct 28, 2025
08:53
Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
10.2K
Classical Hodgkin Lymphoma Presenting as a Sigmoid Mass
Heather Caulkins1, Alyaa Irhayyim1, Lijun Yang1
1Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Gastroenterology Research
|July 16, 2021
Summary
This case report details a rare instance of primary classical Hodgkin lymphoma (CHL) in the colon, presenting as a sigmoid mass. The diagnosis was confirmed through immunohistochemistry and Epstein-Barr virus testing, leading to successful treatment.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Primary classical Hodgkin lymphoma (CHL) of the colon is exceptionally rare.
- It can mimic other gastrointestinal lymphoproliferative disorders.
- Accurate diagnosis is crucial for appropriate management.
Observation:
- An elderly male with a history of mantle cell lymphoma presented with constipation.
- Imaging revealed a sigmoid colon mass.
- Endoscopic biopsy showed ulcerated mucosa with Hodgkin and Reed-Sternberg cells.
Findings:
- Immunohistochemistry revealed positivity for CD30, CD15, and weak Pax-5, with negativity for CD45, CD20, CD3, and SOX-11.
- Epstein-Barr virus (EBV) in situ hybridization was positive.
- The immunophenotype confirmed CHL in the context of a large colonic mass.
Implications:
- This case highlights the diagnostic challenges of rare colonic CHL.
- It underscores the importance of comprehensive immunohistochemistry and EBV testing.
- Successful treatment with colectomy and chemotherapy resulted in complete remission.
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